Best Diaper Rash Cream for Babies

Kids & Baby

One day you’re changing your baby’s diaper and you notice red bumps all over her thighs and bottom. Her skin is bright, red, irritated, and sensitive to the touch. This is a common problem among infants and it’s known as diaper rash. 

But how can you prevent your baby from getting this rash in the future? How can you treat it now before it leads to a worse infection? And what caused it in the first place? We’re hoping to answer all of these questions today and help you find the best diaper rash cream for your baby. 

Comparison Table

What Causes Diaper Rash?

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While a bright red bottom and a crying baby might be an alarming sight, there usually is no reason to fret. If this happens to your baby, don’t panic. There are many causes for diaper rash and usually means nothing serious.

But what is the cause of this rash? How can you stop it from occurring again in the future? We will outline a few of the most common causes of diaper rash in babies.

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Irritation from Moisture in Diapers

Babies have extremely sensitive skin. Even the slightest bit of moisture in a diaper can lead to an outbreak of diaper rash. When your baby’s skin is exposed to the urine or stool left in a diaper for a long period of time, this can make matters even worse.

 To prevent this, make sure diapers are changed as soon as possible and checked often. When a baby is sick with diarrhea, this can make matters even more urgent. Diarrhea is more acidic and is the enemy of your baby’s skin. When your baby is sick, take diaper changing even more seriously.

Diapers and Clothing Which are Too Tight

If you’re squeezing your baby into their clothes, it might be time for a wardrobe change. It turns out; tight clothing can be a major factor contributing to diaper rash. The way tight clothing rubs against the skin causes friction that can eventually lead to diaper rash.

Introducing New Foods

Whenever you start your baby on new food, you’re running the risk of her pooping more frequently throughout the day. The more bowel movements your baby has, the more likely they are to get a diaper rash.

The same is true for breastfeeding babies. Moms, if you eat something out of the ordinary, this could be causing stomach issues for your breastfeeding baby.

Warm Weather

Hotter weather means more sweating, and more sweating means more bacteria building up. A baby’s diaper is the perfect bacteria hotspot to grow and multiply exponentially. Combined with the contaminants that a diaper is already exposed to, sweat makes the possibility of a diaper rash almost guaranteed.

When taking your baby outside in the summer, make sure you’re changing their diaper often, and wiping their bottom to get rid of excess sweat.

Skin Sensitivities

If your baby has sensitive skin or a condition like eczema, it is significantly more likely they will develop a diaper rash. With sensitive babies, changing a diaper more frequently can increase the likelihood of getting a diaper rash.

 When changing your baby with sensitive skin, make sure you’re applying a soothing cream to their bottom every time. 


If your baby is constantly covered in little red bumps, it’s possible they have a bacterial or fungal infection. This is a warm area on the baby’s body with a lot of moisture, making it the ideal spot for bacteria to thrive. If you think this is the case, see a doctor for treatment.


Antibiotics kill bacteria; unfortunately, they take the good bacteria down too. If your baby is on antibiotics, or you are as a breastfeeding mother, this can be what’s causing your baby’s diaper rash. 

 Good bacteria is used to prevent yeast from growing. When this bacteria is destroyed, your baby can get a diaper rash from a yeast infection.

How to Prevent Diaper Rash

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There are a couple of ways parents can prevent diaper rash on their babies to mitigate the need for creams and other ointments. Also, to save your baby from pain and to save yourself a lot of headaches.

  • At first sight of red skin on your baby’s bottom, apply a soothing cream. This will help future redness from popping up.
  • Change your baby’s diaper many times throughout the day. A single diaper used for a long period of time increases the moisture your baby’s bottom is exposed to and increases the chance of rash.
  • Let your baby go diaper free. Granted, this can be a bit messy. But when possible, a bare bottom is best for preventing a rash.
  • During every diaper change, apply cream as a protective layer between your baby’s bottom and the diaper. This will prevent the moisture produced by wearing the diaper from irritating your baby and forming a rash.

Severe Diaper Rash

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A severe diaper rash can be a cause for alarm for many parents. A severe diaper rash is a rash that has gotten so severe that it has reached the infected stage. A diaper rash at this stage usually can’t be treated by traditional creams and ointments. So what is there to do?

If you have a baby with a severe diaper rash, you should take them to the doctor. A pediatrician will be able to prescribe you an over-the-counter cream which can be used to treat your baby’s rash. Many parents use the prescription cream in conjunction with an anti-fungal cream to make the redness and pain go down faster.

Remember that diaper rash is not a problem to be ignored. Although it is extremely common, it can be dangerous to overlook as your baby can easily develop an infection. Make sure you are always checking your baby’s diaper to see if it needs to be changed, and properly cleansing your little one every time.

How to Choose a Diaper Rash Cream

Diaper Rash Cream

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There are several types of diaper rash creams on the market today. While it might be easy to just go to the store and pick one up, it would be unwise to buy a diaper rash cream without knowing what its active ingredients are targeted to treat. 

Here we’ve listed a couple of the basic types of diaper rash creams. Knowing the basics of each kind of cream will help you pick out the right one to treat your baby’s rash best.

Zinc Oxide

Zinc oxide is an extremely popular ingredient in diaper rash creams. This type of cream is best for treating mild infections but isn’t a good choice for more severe rashes. These creams are particularly creamy and feel soothing on your baby’s bottom.

Some common brands that contain zinc oxide are Desitin and Balmex, along with various other generic brands.

Hydrocortisone Cream

Hydrocortisone 1% cream is great for reducing inflammation and redness on your baby’s bottom. When applied in unison with another diaper rash cream, it is very effective in preventing and reducing rash. Simply apply a small layer mo more than once or twice a day.

Butt Paste

While the name is unfortunate, butt paste is great for soothing baby rashes. This compound is only available by prescription and contains zinc oxide as well as other active ingredients to create a layer between your baby’s bottom and their diaper. Some butt pastes contain lanolin or beeswax to prevent rashes.

Antifungal Creams

If you are certain your baby’s diaper rash is from a yeast infection, you will need an antifungal cream to rid your baby of irritation. There are plenty of over-the-counter solutions that contain clotrimazole, miconazole micatin, and nystatin. If these treatments aren’t working, there are also plenty of antifungal creams available by prescription from a doctor. 

pH Restoring Creams

Diaper rash creams have started using pH restoring technology to balance out the acid that is exposed to your baby’s bottom by urine and stool. Acid Mantle is a product that balances the pH in your baby’s diaper to make them less susceptible to the chemicals in their own urine or stool. This product can be used with a zinc oxide cream to soothe the rash as well.


Lanolin is an ointment sheep produce which is used to treat damaged and sensitive skin. This natural solution is popular with parents who don’t want to expose their babies to more chemicals. 

Our Top Picks

Whether your baby has a mild rash or is suffering from a severe infection, we will go over which is the best diaper rash cream for your baby’s unique needs. 

Calming Calendula

California Baby Diaper Rash Cream - Calming - 2.9 oz
  • California Baby
  • Country of origin is United States
  • The package dimension of the product is 5.5"L x 2.1"W x 2.1"H

Who it’s made for: This product is great for treating mild to moderate diaper rash and preventing new rashes from arising. It also uses very few chemicals and no preservatives.

Why we liked it: This formula made with zinc oxide, calendula, chamomile, and almond oil is just as soothing as it is effective. The ingredients are specifically targeted for their anti-inflammatory properties in treating diaper rash. This product works quickly and gets rid of redness and irritation quickly. 

Things to think about: This product isn’t for babies with severe diaper rash. If your baby has worse symptoms than typical red bumps and irritation, you may want to opt for a different product. 

What we rank it: Even though this is a natural product, it doesn’t come at the steep price tag many other organic products do. For only $8, you can use Calming Calendula on your baby’s bottom. We give this product 4.75 out of 5 stars

Mustela Vitamin Barrier Cream 

Who it’s made for: This is the best diaper rash cream for preventing diaper rash from occurring in the first place. It’s gentle enough that you can use on newborns as well. 

Why we liked it: This solution is gentle enough for everyday use. If you’re looking to prevent diaper rash on your little one’s bottom, this is a great choice of diaper rash cream. It’s also fragrance-free, which lessens the possibility of irritation. It’s easy to rub on and wash off. The cream is formulated so when wiped off; no residue is left over to possible irritate your baby’s skin.

Things to think about: While the application of this cream is simple, it does require quite a bit of cream in order to cover the affected area. 

What we rank it: We loved this cream and gave it 4.75 out of 5 stars. You can buy it yourself for $15. 

Desitin Rapid Relief Cream

Desitin Rapid Relief Diaper Rash Remedy, Fragrance-Free Cream, 16...
  • 16-oz tube of zinc oxide diaper rash cream
  • Fast-acting formula helps heal, soothe, and treat diaper rash
  • #1 choice of pediatricians and moms

Who it’s made for: This product works best for babies with a mild diaper rash who need quick soothing comfort. 

Why we liked it: Desitin is great for quick relief. Even from the first use, this product promises to ease your baby’s discomfort and put an end to their crying. In a clinical study testing Desitin cream, 90% of babies with mild to moderate diaper rash were relieved of symptoms after only 12 hours. 

Things to think about: Some have reported that this product has a weird fishy smell. If this will be unpleasant to you or your little one, you may want to avoid this product.

What we rank it: Available for around $12, we give Desitin Rapid Relief Cream 4.5 out of 5 stars.

Aquaphor Baby Healing Ointment

Aquaphor Baby Healing Ointment - Advance Therapy for Diaper Rash,...
  • Multi-purpose solution for your baby's many skin care needs, Aquaphor Baby Healing Ointment is clinically proven to...
  • Provide extra gentle care for your baby’s tender and delicate skin by applying Aquaphor to irritated and chapped skin...
  • Use Aquaphor Ointment as a preventative diaper rash cream and apply with every diaper change to protect the skin from...

Who it’s made for: This is the all-purpose, cult-favorite, baby rash ointment. From head to toe, Aquaphor has your baby’s needs covered...including diaper rash.

Why we liked it: This ointment can be used all over. Rashes, scratches, or dry skin, this is a safe and effective product for your little one. Aquaphor soothes your baby’s diaper rash without any fragrances or possible irritants. 

Things to think about: This product requires a thick layer. If your baby doesn’t enjoy that, Aquaphor has also created another line of diaper rash specific creams using zinc oxide. 

What we rank it: A 14-ounce bottle will cost you less than $10 at most drugstores, making Aquaphor a great deal. We give it 4.5 out of 5 stars


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Who it’s made for: This cream is best suited for babies with severe diaper rash.

Why we liked it: Sudocrem is made for babies who can’t pee or poop without crying. It’s a mild antiseptic that soothes severe diaper rash and forms a water-resistant later which serves as a barrier to help urine and stool from irritating the babies skin. It works great with babies suffering from sensitive skin conditions like eczema, bed sores, and sunburn.

Things to think about: This cream is a bit waxy. It’s not the ultra-soothing cream you might imagine you’ll be using when treating diaper rash. It’s also a bit difficult to wash off. 

What we rank it: For around $10, we rank this cream 4.25 out of 5 stars.

Bepanthen Nappy Rash Ointment

Bepanthen Ointment 100g
  • Bepanthen Nappy Care Ointment is an easy to apply and breathable barrier cream that helps keep little bottoms happy and...
  • Bepanthen contains Pro Vitamin B5 which gently aids natural recovery of sensitive skin while keeping it soft, smooth and...
  • Clinically proven, Bepanthen works by forming a transparent layer protecting even the most delicate skin from irritants...

Who it’s made for: This ointment is great for infants with highly sensitive skin. It’s a great choice for premie babies with ultrasensitive skin. 

Why we liked it: This product contains no fragrance, no preservatives, colors, or antiseptics that could possibly irritate your baby’s skin. It is so gentle that you can use it during every diaper change, even with the most sensitive of babies. It’s also very affordable compared to other sensitive -skin products. 

Things to think about: This formula is very oily. It requires a lot of product to be applied to completely cover the affected area.

What we rank it: Bepanthen ointment is available for around $9. We give it 4.25 out of 5 stars.

Drapolene Cream 

Who it’s made for: This cream works best for babies with a mild diaper rash. The formula is gentle, which helps emerging rashes clear up right away. 

Why we liked it: In addition to being affordable, this product is also readily available in a vast majority of supermarkets. The ingredients used to formulate this cream are soothing and cooling to help soothe any irritation your baby is feeling, and also prevent future infection from diaper rash. 

 Things to think about: If your baby is suffering from anything other than a mild rash, this cream won’t serve very effective.

 What we rank it: For around $8, we rank this cream 4 out of 5 stars.


Polysporin Ointment, 0.5 Oz (4 Pack)
  • UPC 300810798884

Who it’s made for: This product was designed for babies with severe diaper rash needing an antibiotic ointment. 

Why we liked it: This antibiotic ointment uses a petroleum base. Although it’s not exclusively used as a diaper rash ointment, we found it effective in treating even the most severe cases of diaper rash. This ointment can also be used as a healing agent. For parents looking for an all-around solution, this is a great product to buy.

Things to think about: Because of the petroleum base, this product is quite oily. Your baby might not like the feeling of having an oily base rubbed all over their bottom. 

What we rank it: This product is available for $7-8 at most drugstores. We give it 4 out of 5 stars in treating diaper rash. 

Cetaphil Baby Diaper Cream

Cetaphil Baby Diaper Cream with Organic Calendula, Vitamin B5 and E ,...
  • Dermatologist tested and formulated to be gentle enough for infant's skin
  • Paraben free, Colorant Free, Mineral Oil Free, and Hypoallergenic
  • Specially formulated to calm and soothe baby's delicate skin

Who it’s made for: This product is the best diaper rash cream for babies with sensitive skin. It works in treating moderate and mild diaper rash symptoms. 

Why we liked it: Those with sensitive skin know what a lifesaver Cetaphil can be. They now have a diaper rash cream line formulated for sensitive-skin babies. It’s made with zinc oxide as the active ingredient accompanied by calendula and vitamins E and B5 for soothing properties.  We also liked that the cream is soothing and not greasy or over-oily to rub on. 

Things to think about: This product can take a bit longer than others to be effective. It took about a week or two to completely treat diaper rash. 

What we rank it: We give Cetaphil Baby Diaper Cream 4 out of 5 stars. We also liked that it comes in at just around $4 and is available in stores all across the nation. 

Earth Mama Angel Baby Bottom Balm

 Who it’s made for: Babies and parents who want a natural, chemical-free solution to diaper rash. Also great for babies with sensitive skin. 

Why we liked it: The formula of this balm is all natural. This product uses olive oil, shea butter, tea tree, and lavender oil, with St. John’s wort flower extract to provide a completely natural solution. This product also has a nice lavender smell too it, making it a refreshing change from some other natural products that smell less pleasant.

Things to think about: This cream is more on the expensive side because of all the natural ingredients. It also doesn’t contain any ingredients that will actually stabilize and reduce diaper rash. Instead, it’s more intended to soothe existing pain and irritation. 

What we rank it: We gave this product 3.75 out of 5 stars. You can find it online for around $17. 

Before You Buy

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Before you head out to buy the best diaper rash cream for your little one, make sure you’re paying attention to what the diaper rash cream is treating and with what ingredients. You wouldn’t want to buy a cream that only prevents future rashes if your baby is suffering from a severe diaper rash.

Every baby is different, and so is every diaper rash. If your baby is having chronic diaper rash, make sure you’re taking them to a pediatrician to make sure there isn’t a bigger problem going on. Once you’ve found the root of your child’s diaper rash, you can effectively purchase the best diaper rash cream for your baby and prevent future outbreaks. 

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